Japanese Scientists Discover New Islet Transplantation and New Breakthrough in Diabetes Treatment
- Mar 15, 2018 -

The Japan Institute of Physical Chemistry and Fukuoka University have recently announced a new research result. Their researchers found that subcutaneous adipose tissue of the thigh is a suitable site for subcutaneous transplantation of pancreatic islets through animal experiments and is expected to become a new method for the treatment of diabetes.

The islet transplantation used to treat diabetes in the past was mainly to transplant the islet cells into the liver of patients. However, this transplantation method is prone to early rejection reactions. Once problems occur, it will be difficult to remove the transplanted cells and several times of transplantation will be required. Although there have been previous studies of subcutaneous transplantation of islet cells, the survival rate of transplanted islet cells is extremely low.

The new study found that previous subcutaneous transplantation of pancreatic islets often caused insufficient blood flow to allow islet cells to survive because of subcutaneous vascular insufficiency, and most of the subcutaneously transplanted islet cells died. Treatment of a diabetic experimental mouse requires the islet cells of five or six experimental mice.

Therefore, the researchers tried to find a site with sufficient subcutaneous blood flow, and finally found that the subcutaneous fat tissue in the thigh is a site suitable for subcutaneous transplantation of the pancreas, because the blood flow is adequate at this site. In the experiment, the researchers transplanted islet cells into subcutaneous adipose tissue of the rat's thighs, and successfully cured diabetic mice with only a small amount of islet cells.

The researchers said that anatomically, humans and experimental mice have the same subcutaneous adipose tissue, so they can be considered to have the same therapeutic effect in humans. This new transplantation method overcomes many problems in previous transplantation techniques and is expected to become a new method for treating diabetes.

This research has been published in the United States "transplantation" magazine.