New study confirms 110 genes associated with breast cancer risk
- Mar 20, 2018 -

Breast cancer is the highest cancer in women, and it is important to estimate the risk to improve the survival rate of breast cancer patients. British researchers recently discovered 110 genes associated with breast cancer risk through a new sequencing technology, which is expected to pave the way for predicting breast cancer risk through genetic testing.

Researchers at the London Cancer Institute reported in a new issue of Nature's Communications in the United Kingdom that they have analyzed the maps of 63 regions of the genome that are believed to be related to breast cancer, and 33 of them 110 genes were found in the region that may increase the risk of breast cancer.

Finding the genes associated with disease risk is not simple, because DNA fragments interact with completely unrelated segments of the genome, creating a structure called the "DNA loop," which interferes with gene recognition. For this reason, the researchers developed a sequencing technology called Capture Hi-C to analyze the map of high-risk areas of breast cancer.

The vast majority of the newly identified 110 genes were not previously considered to be associated with breast cancer risk. In addition, by referring to patient data, the researchers found that the newly identified 32 genes were associated with the survival rate of estrogen receptor-positive breast cancer patients. They said they would like to further study newly identified genes to determine what role they play in breast cancer.

Olivier Fletcher, head of the Genetics Epidemiology Group at the London Cancer Institute, said: "The discovery of these new genes will help us understand the genetic mechanisms of breast cancer risk in more detail. Ultimately, our research can be adopted. Genetic testing predicts breast cancer risk or paves the way for new targeted therapies."