New technology makes it easy to chemically synthesize insulin
- May 10, 2018 -

Insulin is a substance secreted by pancreatic islet beta cells in the pancreas and can control blood glucose, and many diabetics now require insulin injections. These insulins are usually produced bioengineered rather than chemically synthesized. This is because the insulin molecule consists of two polypeptide chains, which are called A chain and B chain, and it is difficult to assemble them chemically.

Researchers from institutions such as Tohoku University, Tokai University, and Osaka University have collaborated with their German counterparts to discover that A- and B-chains can be assembled together in low-temperature, alkaline solutions that meet specific conditions. The researchers first synthesized bovine insulin using this technique, followed by the synthesis of human insulin.

The researchers said that the advantage of this synthesis method is that it is simple to operate, does not require the use of genetic technology as a bioengineering method, and does not require large-scale equipment. It is hoped that this technology can be transferred from the laboratory to the actual application and further research and development. New methods for producing insulin preparations.

Relevant papers have been published in the online edition of the British Journal of Communications Chemistry.