The new efficacy of caffeine——significantly reduces the risk of acute kidney injury in premature infants
- Apr 09, 2018 -

According to Neonatal Kidney Collaborative recently published in the JAMA Pediatrics, a recent study called "Assessment of Worldwide Acute Kidney Injury Epidemiology," the risk of acute renal injury in newborn babies exposed to caffeine in the first few days of birth is lower than that of undecaffeinated newborns. The severity also declined. Dr. David Askenazi, a professor from the Department of pediatrics at the University of Alabama (UAB), Bermingham, co - author of the study, is also the chairman of Neonatal Kidney Collaborative.

"We have found that 1 out of every 4 premature infants will suffer from acute kidney injury, which will lead to increased hospitalization time, medical expenses, morbidity and mortality." Askenazi said. This new research provides hope for intervention -- caffeine may reduce the risk of acute kidney injury in newborns.

The multicenter cohort study assessed 675 newborns with less than 33 weeks of pregnancy and found that only 11.2% of the newborns exposed to caffeine suffered from acute renal injury, compared with 31.6% in the control group.

In the national neonatal ICU, caffeine is usually used to stimulate newborns, to keep their fully developed lungs and brain work, and caffeine is also used to prevent acute apnea. The new study finds that caffeine can also help kidney.

"The findings of this study will change the clinical use and use of caffeine, and may eventually help reduce mortality and morbidity associated with renal development and related diseases in the newborn." Askenazi said.